The aim of present investigation is to enhance in vitro dissolution of poorly soluble drug albendazole by preparing solid dispersions using modified gum karaya (MGK). Solid dispersions of drug were prepared by solvent evaporation method using modified gum karaya as carrier. Four batches of solid dispersions (SD1, SD2, SD3 and SD4) and physical mixtures (PM1, PM2, PM3 and PM4) were prepared and characterized by differential scanning colorimetry (DSC), fourier transform infrared (FTIR) spectroscopy, powder x-ray diffraction (XRD) and scanning electron microscopy (SEM) studies. Equilibrium solubility studies were carried out in shaker incubator for 24 h and in vitro drug release was determined using USP Dissolution Apparatus II. Result showed that batch SD2 showed maximum solubility and in vitro dissolution. No significant enhancement of dissolution characteristics were observed in the corresponding physical mixture (PM2). Low viscosity and comparable swelling characteristics of modified gum karaya may lead to improvement in dissolution behavior of solid dispersion batches. Also the conversion of crystalline form of drug to amorphous form may be a responsible factor which was further confirmed by DSC, FTIR studies and X-RD studies. SEM photographs of batch SD2 revealed porous nature of particle surface
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